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[av_slide_full slide_type='image' id='186' video='http://' mobile_image='' fallback_link='http://' video_format='' video_ratio='16:9' title='HIV Pre-exposure Prophylaxis (PrEP)' custom_title_size='34' custom_content_size='27' caption_pos='caption_bottom caption_bottom_framed caption_framed' link_apply='' link='lightbox' link_target='' button_label='Click me' button_color='light' link1='manually,http://' link_target1='' button_label2='Click me' button_color2='light' link2='manually,http://' link_target2='' font_color='' custom_title='' custom_content='' overlay_opacity='0.5' overlay_color='' overlay_pattern='' overlay_custom_pattern='' av-medium-font-size-title='' av-small-font-size-title='' av-mini-font-size-title='' av-medium-font-size='' av-small-font-size='' av-mini-font-size='' av_uid='av-8mvpp']
Sanguen offers access to the anti-retroviral medication PrEP to persons at risk of HIV infection.
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<h2 style="text-align: center;">WHAT IS HIV PrEP?</h2>
<p>PrEP is the administration of a combination anti-retroviral medication (tenofovir DF/ emtricitabine 300/200 mg, Truvada) to HIV-uninfected individuals at high and ongoing risk of HIV acquisition to prevent HIV.</p>
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<h3 style="text-align: center;">Who Should Be Considered For HIV PrEP?</h3>
    <ul>
     <li>PrEP is recommended for MSM and trans-F with a HIRI-MSM score > 10 - 11</li>
     <li>PrEP is recommended for MSM and trans-F who have had condomless anal intercourse within 12 months AND have infectious syphilis or rectal STI OR have recurrent use of HIV post-exposure prophylaxis OR have an ongoing sexual relationship with HIV + partner with viral load > 40 copies/mL </li>

    <li>PrEP is recommended for the HIV-negative partner in a heterosexual serodiscordant relationship where condomless anal or vaginal sex is occurring in the context of a substantial or non-negligible risk of transmission (negligible risk is defined as some with a viral load < 40 copies/mL AND no known STIs present at time of exposure)</li>

    <li>PrEP may be considered for individuals who use injection drugs if they share injection drug use paraphernalia</li>
<p> </p>

<h3 style="text-align: center;">What Is The HIRI-MSM?</h3>
The HIV Incidence Risk Index for MSM (HIRI-MSM) is a validated risk tool. A score of 10 corresponds with a 2% annual risk of HIV acquisition; a score of 25 corresponds with a 7% annual risk.
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(source: Tan DHS, Hull MW, Yoong D, et al, 2017, Appendix 1 p.37)
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<h3 style="text-align: center;">What Are The Most Common Side Effects And Possible Risks Of PrEP?</h3>
Truvada is extremely well tolerated, with some minor transient GI sx and headache possible in the first week.  There can be some impacts on bone density that appear reversible upon discontinuation.  Renal function needs to be monitored.  

Truvada is a treatment for hepatitis B, and discontinuing it in someone who has Hepatitis B can cause a flare; Hepatitis B screening is part of the initial work up, and vaccination is recommended in individuals who are non-immune. 

If an individual taking PrEP acquires HIV, they may develop drug-resistant infection. Anyone with symptoms of acute retroviral syndrome (fever, headache, myalgia, sore throat) should be assessed and tested.  
<p> </p>
<h3 style="text-align: center;">What Baseline Testing And Monitoring Should Be Done?</h3>
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(source: Tan DHS, Hull MW, Yoong D, et al, 2017, p. E1453)

References: 

Tan DHS, Hull MW, Yoong D, et al. Canadian Guidelines on HIV pre-exposure prophylaxis and non-occupational postexposure prophylaxis. CMAJ. 2017. 189:E1448-58. doi: 10.1503/cmaj.170494

Appendix to: Tan DHS, Hull MW, Yoong D, et al. Canadian Guidelines on HIV pre-exposure prophylaxis and non-occupational postexposure prophylaxis. CMAJ. 2017. Doi: 10.1503/cmaj
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